A gunman took several people hostage earlier on Saturday and threatened to detonate a bomb, Reuters reported.
It was unclear how many people were still being held after three employees were seen by reporters fleeing the area with their hands above their heads.
There was no indication of a terrorist motive, police said.
Several special police units were deployed to the scene, a building in the center of town, police said in a post on social media. They said 150 homes had been evacuated and the public was asked to stay away from the area.
People were being held at the Petticoat nightclub by a man with weapons and explosives, the national newspaper de Telegraaf reported, citing several anonymous sources.
A reporter for broadcaster NOS said a remote-controlled robot was at the scene as well as anti-explosive units and police in protective gear.
Trains to and from Ede were canceled, railway operator NS said on its website.
SD/PR